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Case report
- Negative myoclonus associated with tramadol use
- Seong Yoon Bae, Se-Jin Lee
- Yeungnam Univ J Med. 2020;37(4):329-331. Published online April 23, 2020
- DOI: https://doi.org/10.12701/yujm.2020.00108
- 6,611 View
- 179 Download
- 1 Crossref
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Abstract
PDF - Negative myoclonus (NM) is a shock-like jerky involuntary movement caused by a sudden, brief interruption of tonic muscle contraction. NM is observed in patients diagnosed with epilepsy, metabolic encephalopathy, and drug toxicity and in patients with brain lesions. A 55-year-old man presented with NM in both his arms and neck. He has taken medications containing tramadol at a dose of 80–140 mg/day for 5 days due to common cold. He had no history of seizures. Acute lesions were not observed during magnetic resonance imaging, and abnormal findings in his laboratory tests were not noted. His NM resolved completely after the discontinuation of tramadol and the oral administration of clonazepam. Our case report suggests that tramadol can cause NM in patients without seizure history or metabolic disorders, even within its therapeutic dose.
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Citations
Citations to this article as recorded by
- Tramadol Induced Jerks
Waiz Wasey, Imad Aziz, Sharefi Saleh, Naila Manahil, Neha Wasey
Cureus.2021;[Epub] CrossRef
- Tramadol Induced Jerks
Case Report
- Negative myoclonus associated with pregabalin
- Kwan-Do Park, Min-Ku Kim, Se-Jin Lee
- Yeungnam Univ J Med. 2018;35(2):240-243. Published online December 31, 2018
- DOI: https://doi.org/10.12701/yujm.2018.35.2.240
- 5,639 View
- 81 Download
- 4 Crossref
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Abstract
PDF
- Negative myoclonus (NM) is a jerky, shock-like involuntary movement caused by a sudden, brief interruption of muscle contraction. An 80-year-old man presented with multifocal NM and confusion. Two days before the onset of NM, he commenced the intake of pregabalin at a dose of 150 mg/day for neuropathic pain. His NM resolved completely and mental status improved gradually after the administration of lorazepam intravenously and the discontinuation of pregabalin. Our study suggests that pregabalin can cause NM even in patients without a history of seizures.
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Citations
Citations to this article as recorded by- Movement disorders associated with antiseizure medications: A systematic review
Daniel J. Zhou, Spriha Pavuluri, Isha Snehal, Cynthia M. Schmidt, Miguel Situ-Kcomt, Olga Taraschenko
Epilepsy & Behavior.2022; 131: 108693. CrossRef - Electrophysiological characteristics and anatomical differentiation of epileptic and non-epileptic myoclonus
Mohammad Abu-Hegazy, Azza Elmoungi, Eman Eltantawi, Ahmed Esmael
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery.2021;[Epub] CrossRef - Pregabalin-associated movement disorders: A literature review
JamirPitton Rissardo, AnaLetícia Fornari Caprara
Brain Circulation.2020; 6(2): 96. CrossRef - Negative myoclonus associated with tramadol use
Seong Yoon Bae, Se-Jin Lee
Yeungnam University Journal of Medicine.2020; 37(4): 329. CrossRef
- Movement disorders associated with antiseizure medications: A systematic review
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