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JYMS : Journal of Yeungnam Medical Science

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HOME > J Yeungnam Med Sci > Volume 15(1); 1998 > Article
Original Article Comparison of Three Third-generation Anti-HCV Enzyme Immunoassay Tests.
Hee Soon Cho, Jin Young Moon, Chae Hoon Lee, Kyung Dong Kim
Journal of Yeungnam Medical Science 1998;15(1):143-150
DOI: https://doi.org/10.12701/yujm.1998.15.1.143
Published online: June 30, 1998
Department of Clinical Pathology College of Medicine, Yeungnam University Taegu, Korea.
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The aim of this study was to evaluate domestic enzyme immunoassay(EIA) kit ?LG HCD 3.0?(LG) for the detection of antibody to hepatitis C virus(anti-HCV) in comparision with Axsym HCV version 3.0(Axsym), Cobas Core anti-HCV EIA(Cobas). Cobas kit shows better clear distinction between positive and negative by signal/cutoff ratio(S/C), but it also reveal relatively high false positive rate. The concordance rate of test results between LG and Axsym was 96.2%, between LG and Cobas was 95.5%, and total agreement between three EIA kit was 93.9%. LG were relative poor distinction between positive and negative results, but it could be applied clinically as a screening tool for hepatitis C in general population. The S/C of one false negative result by LG was 0.91, and false positive were less than 4.0, therefore we concluded it is necessary to confirm by immunoblotting assay when S/C were between 0.8 and 4.0.

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JYMS : Journal of Yeungnam Medical Science