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Yeungnam Univ J Med > Volume 33(2); 2016 > Article
Yeungnam University Journal of Medicine 2016;33(2):125-129.
DOI:    Published online December 31, 2016.
A patient with stress induced cardiomyopathy that occurred after cessation of hormone replacement therapy for panhypopituitarism.
Seoung Wan Nam, Jun Won Lee, Jeong Han Sim, Hyun Sung Pack, Changjo Im, Jung Soo Lim, Sung Gyun Ahn
Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Stress induced cardiomyopathy (SC) is characterized by transient left ventricular (LV) dysfunction in the absence of coronary artery disease. We report on a patient with panhypopituitarism who developed SC resulting from withdrawal of hormonal replacement therapy (HRT). A 52-year-old male visited our hospital for progressively worsening dyspnea. The patient had discontinued HRT 7 days ago, which had been administered for 18 months after transsphenoidal adenomectomy for pituitary macroadenoma. Initial electrocardiogram showed marked sinus bradycardia. Transthoracic echocardiography showed apical ballooning with an LV ejection fraction of 25%. No significant obstructive lesions were observed on coronary angiography. With a clinical diagnosis of SC associated with panhypopituitarism, HRT was restarted, including glucocorticoid and thyroxine, along with standard heart failure management. His LV function had normalized at 2-month follow-up. He remains asymptomatic and administration of beta-blocker and angiotensin converting enzyme inhibitor were discontinued He currently only requires HRT.
Key Words: Takotsubo cardiomyopathy, Stress cardiomyopathy, Hypopituitarism
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