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Yeungnam Univ J Med > Volume 5(2); 1988 > Article
Yeungnam University Journal of Medicine 1988;5(2):95-100.
DOI:    Published online December 31, 1988.
The Bronchodilatory Effect of Ipratropium Bromide on Bronchial Asthma.
Jae Hee Ahn, Tae Nyeon Kim, Young Hyeun Lee, Jae Chun Chung, Hyun Woo Lee
Ipratropium bromide (IP) is a new anticholinergic bronchodilator. To evaluate its effect on bronchial asthma which is still unknown in Korea, a double blind and randomized study was done on all patients of bronchial asthma who visit out-patients clinic of out department from June to September 197 and showed 75 to 100% of FEV1/FVC ratio on prebronchodilator spirometry (pre BD). The selected patients were given 2 puffs of Fenoterol (FE) or Ipratropium inhalator blindly and Spirometry. The repeated results are: 1. In both FE and IP groups, there was a significant bronchodilatory effect on 5 and 60 minutes after administration. 2. One 5 minutes, effect of FE was significantly greater than IP (FVC p<0.05, FEV1 p<0.01). 3. One 60 minutes, effect of IP was slightly less than FE but statistically non-significant. On the basis of above results, we concluded that onset of effect of IP is slower than FE, but its effect is significant and nearly comparable to FE.
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