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Yeungnam Univ J Med > Volume 15(1); 1998 > Article
Yeungnam University Journal of Medicine 1998;15(1):47-54.
DOI:    Published online June 30, 1998.
The effect of interleukin-10 on KC gene expression in mouse peritoneal macrophages.
Hee Sun Kim
Department of Microbiology, College of Medicine , Yeungnam University, Taegu, Korea.
Interleukin-10(IL-10) inhibits production of a wide range of cytokines in various cell types and transcriptionally inhibits lipopolysaccharide(LPS)-induced expression of proinflammatory mediators. Cytokine expression by macrophages is an important aspect to ochestrate inflammatory responses. As an approach to identify mechanistic targets of IL-10, it was examined the time course for expression of KC(murine homologue of Gro) gene in murine peritoneal macrophages stimulated with LPS with or without IL-10. The effect of IL-10 on LPS induced KC mRNA expression was delayed and only seen after 1 hour treatment. Pretreatment with IL-10 did not eliminate the delayed inhibitory response nor increase the magnitude of suppression. These effects did not depend upon time of IL-10 treatment but the time of LPS treatment. LPS-induced KC mRNA expression by inhibitoy action of IL-10 was not controlled at the level of transcription. The result indicates that IL-10 acts late in the process of KC gene expression and that the prominant site of action may be mRNA stability or translation.
Key Words: KC, interleukin-10(IL-10)


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