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Yeungnam Univ J Med > Volume 34(1); 2017 > Article
Yeungnam University Journal of Medicine 2017;34(1):128-131.
DOI:    Published online June 30, 2017.
Severe chest pain with mid-ventricular obstruction in a patient with hyperthyroidism
Jong Ho Nam, Jang Won Son, Geu Ru Hong
1Cardiology Division, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.
2Division of Cardiology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea.
Mid-ventricular obstruction (MVO) rarely occurs in patients without hypertrophic cardiomyopathy. Increased cardiac contractility may play an important role in causing MVO. We experienced a case of severe chest pain and MVO in a 50-year-old female patient. She had hypertension, diabetes, stroke and peripheral artery disease. Her blood pressure was very high (222/122 mmHg) with severe fluctuation. The transthoracic echocardiography revealed MVO accompanied by hyper-dynamic left ventricular systolic function. We regarded her chest pain and MVO as secondary findings related to other diseases. Coronary angiography and several tests for uncontrolled hypertension were performed, and those evaluations revealed that she had coronary artery disease and hyperthyroidism. We considered that the increase in the myocardial oxygen demand in response to the increase in cardiac contractility and workload associated with hyperthyroidism aggravated her symptoms and MVO. She was treated with methimazole and beta blockers and her symptoms dramatically improved.
Key Words: Hyperthyroidism, Coronary artery disease, Ventricular function


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