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Yeungnam Univ J Med > Volume 33(1); 2016 > Article
Yeungnam University Journal of Medicine 2016;33(1):40-43.
DOI: https://doi.org/10.12701/yujm.2016.33.1.40    Published online June 30, 2016.
Rapidly resolved IgG4-related retroperitoneal fibrosis after steroid pulse therapy.
Soomin Jeung, Hyosang Kim, Yuri Seo, Hee Young Yoon, Nah Kyum Lee, Shinhee Park, Bomi Seo, Su Yeon Park, Su Kil Park
1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. skpark@amc.seoul.kr
2Division of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Abstract
Retroperitoneal fibrosis (RF) is a disorder characterized by the presence of a retroperitoneal mass and concurrent systemic inflammation. Some cases of RF are recognized as belonging to the spectrum of immunoglobulin G4-related disease (IgG4-RD). Glucocorticoids are highly effective for treatment of retroperitoneal fibrosis, although the optimal dose and duration of therapy have not been established. An initial dose of prednisone (40-60 mg) daily is usually administered with a tapering scheme. We report on a 55-year-old man diagnosed with IgG4-related RF and successfully treated with a 3-day course of daily 250 mg (4 mg/kg) intravenous methylprednisolone, which resulted in the prompt resolution of urinary obstruction and systemic symptoms.
Key Words: Glucocorticoids, IgG4-related disease, Retroperitoneal fibrosis, Steroid pulse therapy
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