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Yeungnam Univ J Med > Volume 29(2); 2012 > Article
Yeungnam University Journal of Medicine 2012;29(2):102-105.
DOI: https://doi.org/10.12701/yujm.2012.29.2.102    Published online December 31, 2012.
A Case of Idiopathic Collapsing Glomerulopathy Showing Aggravation on a Chronic Progressive Course.
Jung Min Park, Mun Ju Hwang, Yo Han Jeong, Hansol Lee, Jong Won Park, Yong Jin Kim
1Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Korea. jwpark@med.yu.ac.kr
2Department of Pathology, College of Medicine, Yeungnam University, Daegu, Korea.
Abstract
Collapsing glomerulopathy (CG) has become an important cause of end-stage renal disease (ESRD). First delineated from other proteinuric glomerular lesions in the 1980s, CG is now recognized as a common, distinct pattern of proliferative parenchymal injury that portends a rapid loss of renal function and poor responses to empirical therapy. The first cases in the literature trace back to human-immunodeficiency-virus (HIV)-negative patients who underwent biopsy in 1979. A 45-year-old male patient complained of hematuria and proteinuria eight years ago. He showed an abrupt serum creatinine increase from 1.75 to 2.65mg/dL in the last preceding months. Afterwards, his serum creatinine progressively increased up to 6.82mg/dL. Moreover, his 24 h urine protein level was determined to have reached 6,171 mg/day, as opposed to 670 mg/day a year earlier. Consequently, renal biopsy was performed, and its result showed collapsing glomerulopathy, compatible with the diagnosis. He has undergone continuous ambulatory peritoneal dialysis as renal replacement therapy. Thus, it is reported herein that a patient clinically diagnosed with chronic kidney disease eight years ago showed a sudden renal-function decrease and was clinicopathologically diagnosed with collapsing glomerulopathy based on the results of his renal biopsy.
Key Words: Focal segmental glomerulosclerosis
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