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Yeungnam Univ J Med > Volume 29(2); 2012 > Article
Yeungnam University Journal of Medicine 2012;29(2):73-76.
DOI:    Published online December 31, 2012.
Obesity and Insulin Resistance in Childhood.
Kwang Hae Choi
Department of Pediatrics, College of Medicine, Yeungnam University, Daegu, Korea.
More and more children are becoming obese and overweight due to several factors that include a high energy density in the diet (a high fat intake) and low energy expenditure. Consequently childhood obesity is becoming a significant health problem. Fat tissue releases many cytokines such as resistin, tumor necrosis factor-alpha, leptin, interleukin-6. These adipocytokines induce obesity-related insulin resistance. Insulin resistance is a key component of obesity-related metabolic problems such as hypertension, type 2 diabetes mellitus, dyslipidemia, non-alcoholic steatohepatitis, acanthosis nigricans and polycystic ovarian syndrome. This review article focused on insulin resistance and its related metabolic diseases.
Key Words: Childhood obesity, Insulin resistance, hypertension, Non-alcoholic steatohepatitis, Polycystic ovarian syndrome


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