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Yeungnam Univ J Med > Volume 28(1); 2011 > Article
Yeungnam University Journal of Medicine 2011;28(1):99-104.
DOI:    Published online June 30, 2011.
A Case of Essential Thrombocythemia Presenting as Esophageal Varix Bleeding and Multiple Thrombosis.
So Yeon Yoon, Jun Hyeok Choi, Sun Mi Kang, Jung Nam Cho, Sung Hwa Bae, Hun Mo Ryoo
Division of Hemato-Oncology, Department of Internal Medicine, School of Medicine, Catholic University of Daegu, Republic of Korea.
Essential thrombocythemia (ET), a subcategory of chronic myeloproliferative disorder, is characterized by absolute thrombocytosis due to excessive clonal proliferation of platelets, hyperaggregability of platelets, and increased incidence of thrombosis and hemorrhage. We consider a diagnosis of ET when an unexplained and persistent thrombocytosis is observed. It is difficult to consider ET first when we meet a patient with esophageal varix bleeding or unusual multiple thromboses like mesenteric vein, splenic vein, and portal vein. This article reports a patient who presented initially with esophageal varix bleeding and unusual multiple thromboses, thereafter, she was diagnosed with ET after testing positive for the Janus Tyrosine Kinase 2 (JAK2) V617F mutation. In conclusion, in patients with varix bleeding and unusual multiple thromboses, myeloproliferative disorders like essential thrombocythemia should be considered as a potential cause and testing for the JAK2 mutation is warranted.
Key Words: Essential thrombocythemia, Esophageal varix, Thrombosis, JAK2


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