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Yeungnam Univ J Med > Volume 26(2); 2009 > Article
Yeungnam University Journal of Medicine 2009;26(2):102-107.
DOI:    Published online December 31, 2009.
The Effect of Probiotic on Constipation in Rats.
Jin Hee Kim, Sung Chul Park, Jong Yeon Kim, Yoon Ki Park
Department of Obstetrics and Gynecology, College of Medicine, Yeungnam University, Daegu, Korea.
BACKGROUND: Constipation is one of the most common disorders in Korea and Western countries. It may be related with life style, diet, physical activity, age, stress and gender, and particularly premenopausal women experience constipation more often than men due to the significant prolongation of the mean colonic transit in women. The aim of this study was to evaluate the effect of a probiotic on constipation in loperamide-induced constipated rats. MATERIALS AND METHODS: The rats were divided into 3 groups. Constipation was induced by administration of loperamide for 5 days, and the excreted amount as well as the number of feces was observed. Lactic acid bacteria as a probiotic were administered orally every day for 5 days. RESULTS: The results showed that loperamide administration induced severe experimental constipation in rats. The amount of feces was decreased and the number of pellets was increased by loperamide. The water content in the feces as a parameter of constipation was also decreased by loperamide. On the other hand, the dry weights of feces were not significantly different among the groups. It represents that the amount of food consumption might have been similar among the groups, and constipation was caused by delayed intestinal movement. CONCLUSION: Probiotic administration for 5 days in rats partly alleviated or prevented the constipation induced by loperamide.
Key Words: Probiotics, Constipation, Loperamide, Rat


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