Yeungnam Univ J Med Search


Yeungnam Univ J Med > Volume 26(1); 2009 > Article
Yeungnam University Journal of Medicine 2009;26(1):1-14.
DOI:    Published online June 30, 2009.
Adult Mesenchymal Stem Cells for Cell Therapy in Clinical Application.
In Hwan Song
Department of Anatomy, Collage of Medicine, Yeungnam University, Daegu, Korea.
Human bone marrow-derived mesenchymal stem cells (MSCs) are a rare population of undifferentiated cells that have the capacity of self renewal and the ability to differentiate into mesodermal phenotypes, including osteocytes, chondrocytes, and adipocytes in vitro. Recently, MSCs have been shown to reside within the connective tissue of most organs, and their surface phenotype has been well analyzed. Many reports showed that transplanted MSCs enhanced regeneration as well as functional improvement of damaged organs and tissues. The wide differentiation plasticity of MSCs was expected to contribute to their demonstrated efficacy in a wide variety of experimental animal models and in human clinical trials. However, new findings suggest that the ability of MSCs to alter the tissue microenvironment via secretion of soluble factors may contribute more significantly than their capacity for differentiation in tissue repair. This review describes what is known about the cellular characteristics and differentiation potential of MSCs, which represent a promising stem cell population for further applications in regenerative medicine.
Key Words: Mesenchymal stem cell, Cell therapy, Clinical application, Differentiation
Share :
Facebook Twitter Linked In Google+ Line it
METRICS Graph View
  • 1 Crossref
  • 139 View
  • 0 Download
Related articles in Yeungnam Univ J Med


Browse all articles >

Editorial Office
170 Hyeonchung-ro, Nam-gu, Daegu 42415, Korea
Tel: +82-53-640-6832    Fax: +82-53-651-0394    E-mail:                

Copyright © 2019 by Yeungnam University College of Medicine. All rights reserved.

Developed in M2community

Close layer
prev next