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Yeungnam Univ J Med > Volume 23(1); 2006 > Article
Yeungnam University Journal of Medicine 2006;23(1):62-70.
DOI:    Published online June 30, 2006.
Effect of Progesterone on COX-2 Expression and Proliferation of Prostate Stromal Cell.
Soo Ryun Jung, Sung Han Kim, E Hwa Choi, Ji Eun Park, Eun Mi Jeon, Young Jin Kang, Kwang Youn Lee, Hyoung Chul Choi
1Senior grade, College of Medicine, Yeungnam University, Daegu, Korea.
2Department of Pharmacology, College of Medicine, Yeungnam University, Daegu, Korea.
BACKGROUND: Benign prostatic hyperplasia (BPH) is the most common benign tumor in older men; the etiology of this disease remains poorly understood. Testosterone and dihydrotestosterone (DHT) both act as androgen via a single androgen receptor. Testosterone is converted to DHT by 5alpha-reductase in prostatic stromal cells. Progesterone has been reported to inhibit DHT conversion; howevwe, its effect on prostatic stromal cells remains to be elucidated. MATERILAS AND METHODS: In this experiment, we investigated the effect of progesterone on androgen receptor expression induced by DHT. We also tested the effect of progesterone on cyclooxygenase-2 (COX-2) expression, as well as prostate stromal cell proliferation using the cell count kit-8. RESULTS: Progesterone did not cause an increase of prostate stromal cell proliferation. The mRNA expression of the androgen receptor and COX-2 were not changed by progesterone; the expressions of androgen receptor and COX-2 proteins were decreased by progesterone in prostate stromal cells. CONCLUSION: These results suggest that in prostate stromal cells, progesterone decreases androgen receptor protein expression, which results in decrement of COX-2 protein expression. This effect might be mediated by post-transcriptional regulation.
Key Words: Prostate stromal cell, Progesterone, Cyclooxygenase-2


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