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Yeungnam Univ J Med > Volume 22(2); 2005 > Article
Yeungnam University Journal of Medicine 2005;22(2):259-265.
DOI:    Published online December 31, 2005.
Langerhans Cell Histiocytosis with Central Diabetes Insipidus: A Case Report.
Jin Ho Kim, Jun Sung Moon, Sun Jung Mun, Ji Eun Lee, Jae Won Choi, Mi Jung Eun, Kyung A Chun, Ihn Ho Cho, Ji Sung Yoon, Kyu Chang Won, Kyung Hee Lee, Duk Seop Shin, Hyoung Woo Lee
1Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Korea.
2Department of Nuclear Medicine, College of Medicine, Yeungnam University, Daegu, Korea.
3Department of Orthopedics, College of Medicine, Yeungnam University, Daegu, Korea.
Central diabetes insipidus (DI) is a syndrome characterized by thirst, polydipsia and polyuria. Langerhans cell histiocytosis is one of the etiologies of DI. Recently we experienced a central DI associated with Langerhans cell histiocytosis. The 44 years old female patient complained right hip pain, polydipsia and polyuria. We carried out water deprivation test. After vasopressin injection, urine osmotic pressure was increased from 109 mOsmol/kg to 327 mOsmol/kg (300%). Brain MRI showed a thickened pituitary stalk and air bubble like lesions sized with 5cm, 7cm was shown on fifth L-spine and right hip bone at hip bone CT. CT guided biopsy revealed abnormal histiocytes proliferation and abundant lymphocytes. The final diagnosis was central DI associated with systemic Langerhans cell histiocytosis invading hip bone, L-spine and pituitary stalk. Desmopressin and etoposide chemotherapy were performed to the patient.
Key Words: Diabetes insipidus, Langerhans cell histiocytosis


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