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Yeungnam Univ J Med > Volume 21(2); 2004 > Article
Yeungnam University Journal of Medicine 2004;21(2):237-241.
DOI:    Published online December 31, 2004.
A Case of Complete Remission of Hairy Cell Leukemia by 2-Chlorodeoxyadenosine.
Yong Gil Kim, Sang Jin Lee, Min Kyung Kim, Kyung Hee Lee, Myung Soo Hyun, Hee Sun Cho
1Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Korea.
2Department of Laboratory Medicine, College of Medicine, Yeungnam University, Daegu, Korea.
Hairy cell leukemia (HCL) is an uncommon chronic B-cell lymphoproliferative disorder that is characterized by cytopenia, splenomegaly, and mononuclear cells displaying cytoplasmic projections. We experienced a case of hairy cell leukemia that developed in a 38-year-old man. He showed marked splenomegaly without palpable lymphoadenopathy. A complete blood cell count revealed leukopenia (3300/microliter with 63% of lymphocyte) and the peripheral blood smear showed abnormal lymphoid cells with cytoplasmic projections. The bone marrow smear revealed abnormal lymphocytes and severe myelofibrosis. Tartrate-resistant acid phosphatase reactivity was strongly positive in the hairy cells. The immunophenotyping results of lymphoid cells were CD5 (-), CD10 (-), CD19 (+), CD25 (+), CD103 (+), CD20 (+), lambda (+). The patient was treated with 2-Chlorodeoxyadenosine at a daily dose of 0.1mg/Kg by a continuous intravenous infusion for 7 days. The patient achieved complete remission.
Key Words: Hairy cell leukemia, 2-chlorodeoxyadenosine, Complete remission


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