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Yeungnam Univ J Med > Volume 21(2); 2004 > Article
Yeungnam University Journal of Medicine 2004;21(2):231-236.
DOI:    Published online December 31, 2004.
A Case of Congenital Factor VII Deficiency Presented with Subacute Subdural Hematoma.
Min Kyoung Kim, Sang Jun Shin, Kyung Ok Kim, Kyung Hee Lee, Myung Soo Hyun, Hee Soon Cho
1Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Korea.
2Department of Laboratory Medicine, College of Medicine, Yeungnam University, Daegu, Korea.
A congenital factor VII deficiency is a rare disorder with an estimated incidence in the western contries of one in 500, 000. Because factor VII is important in initiation the coagulation cascade, a factor VII deficiency can result in significant bleeding with prolongation of the prothrombin time. We present a case of a factor VII deficiency with a subdural hematoma in an 18-year-old boy whose plasma activity of factor VII was < or =10%. Previously, he did not have any symptoms, such as hemarthrosis, easy bruising or bleeding after a minor trauma. He was administered fresh frozen plasma and a trephination was performed. His sister also had 51% lower level of factor VII.
Key Words: Factor VII deficiency, Prothrombin time


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